PCORI sought to develop a dissemination and implementation (D&I) framework to facilitate strategic planning for sharing information and for putting new evidence into practice to speed change. In February 2014, PCORI enlisted a team led by Mathematica Policy Research to develop this Framework, and a companion Toolkit, through a review of the D&I literature in health and healthcare, discussions with D&I experts, and feedback from more than 300 people representing 15 stakeholder groups, including the Agency for Healthcare Research and Quality. The goal of the Framework and Toolkit is to help speed and enhance the use of patient-centered outcomes research (PCOR) and comparative effectiveness research (CER) in healthcare-related decision making, in turn leading to improve patient outcomes. The Toolkit makes existing best practices for D&I accessible and actionable, and it enables users to build on those best practices when planning and conducting D&I activities.