This brief summarizes key findings from a study of the implementation of the Teen Choice curriculum, a 12-session program that uses interactive exercises and guided discussions to deliver information to groups of 8 to 12 students on abstinence, contraception, sexually transmitted infections, and healthy relationships. With funding from a Personal Responsibility Education Program (PREP) grant, Inwood House—a nonprofit agency that developed the curriculum—implemented the program in New York City-area alternative schools for youth with emotional, behavioral, and academic challenges. The implementation study was conducted in conjunction with a rigorous impact study, in which students who agreed to take part in the study were randomly assigned to receive Teen Choice or their regular programming.