Home visiting is generally a prevention strategy aimed to support parenting and child development. Given that programs target expectant parents and families with young children and that they can be tailored to fit each individual family’s needs, they are well positioned to reach families at risk of or experiencing substance use issues, and can play an important role in engaging and supporting families to prevent, identify, and address these issues. However, more information is needed about how to integrate evidence-based practices for working with families on these issues into programs. This project helps to fill this gap by providing stakeholders with a summary of what is generally known and what needs to be learned. This report describes project findings around six touchpoints and four implementation system inputs through which home visiting programs can engage and support families to prevent, identify, and address substance use issues.