AI/AN FACES 2015 is the first national study of Region XI AI/AN Head Start children and their families, classrooms, and programs. This set of tables presents data on the demographic backgrounds and developmental outcomes of children enrolled in Region XI AI/AN Head Start programs during the 2015–16 Head Start year. The tables also detail aspects of their home environment and family life. Data on children’s classrooms, teachers, centers, and programs, including aspects of classroom quality and practice, teacher and director characteristics, and characteristics of the center and program environments, provide context for children’s experiences. We also provide information on the AI/AN FACES 2015 study methodology and collaborative design process, sample, and measures. The study design, implementation, and dissemination have been informed by extensive collaboration with a workgroup comprised of Head Start directors from Region XI programs, early childhood researchers with experience working with tribal communities, Mathematica researchers, and federal government officials. The AI/AN FACES 2015 child sample was selected to represent all children enrolled in Region XI Head Start in fall 2015, drawing on participants from 21 randomly selected Region XI programs from across the country. AI/AN FACES 2015 includes a battery of child assessments across many developmental domains; surveys of children’s parents, teachers, and program managers; and classroom observations. The study is conducted by Mathematica Policy Research and its partner—Educational Testing Service—under contract to the Office of Planning, Research, and Evaluation, Administration for Children and Families, U.S. Department of Health and Human Services.