This handbook describes the methods used by the Home Visiting Evidence of Effectiveness (HomVEE) review to review existing research and report the findings. It is designed for use by researchers, policymakers, and other stakeholders. For the first time since its inception, HomVEE has substantially revised several procedures and standards for its review. HomVEE consulted with methodological experts and other federal evidence reviews to refine and update the procedures and standards in this document. These changes bring HomVEE generally into alignment with procedures and standards for other federally sponsored systematic evidence reviews, and they address critical topics in the evolution of the home visiting field. HomVEE will apply these procedures and standards beginning with the 2021 annual review.