The goal of the evaluation is to assess the harm reduction during the period when all three engines (CMMI, federal partners, and private partners) were engaged simultaneously in an extraordinary effort to meet the common goals. This report provides an interim assessment of the PfP campaign’s progress towards reducing hospital-acquired harms, based on the synthesis of evidence across multiple data sources and using multiple analytic techniques. The national scale of PfP makes it challenging to assess its overall impacts, as there is little opportunity to identify the progress that would be made in its absence. However, it is important to assess PfP’s overall progress towards its goals, even if more rigorous analyses examining specific features or components of PfP must wait for more complete data to become available.