The U.S. Department of Labor’s Office of the Disability Employment Policy and its federal partners seek to build the evidence base for promising strategies to improve the employment outcomes for youth ages 14 to 24 who receive Supplemental Security Income. The purpose of this report, the final of three research reports for the project, is to identify promising interventions that could assist youth with disabilities. This report builds on findings from the project’s first two reports, which summarized previous evidence on intervention models for youth with disabilities and options to identify target populations of youth. As part of both reports, we reviewed findings from the literature and received input from the Community of Practice on options for intervention and target populations. The report includes a summary of the findings from the two previous reports, which we use to create a menu of intervention and target population options. We then identify criteria to guide policymakers more broadly, and federal policymakers specifically, on their options for selecting interventions that could inform future policy decisions to promote sustained, gainful employment. We offer four examples to illustrate how policymakers could use these criteria to select options to meet their policy objectives.