At least 78 million people worldwide have autism, yet many people do not receive supports from or have access to suitable health care, education, and social services. Lack of access to these supports can lead to people with autism experiencing poor outcomes in areas such as educational attainment, steady employment, and long-term health and well-being. In addition to emphasizing improving systems of care, the Lancet Commission has developed several action-oriented recommendations to address these challenges and potentially improve outcomes for people with autism over the next five years.