In this report, we present a framework for developing evidence-building plans and describe the experiences of evaluation leaders from seven agencies who delivered presentations in the HHS ASPE-sponsored webinar series from July to August 2019. The report summarizes the steps for developing evidence-building plans and highlights lessons learned for those interested in or currently developing such a plan. The report describes: 1) infrastructure and processes to support data collection and analysis, including the development of an evidence-building plan; 2) the approaches that federal agencies participating in the HHS ASPE webinar series used when implementing their learning agendas; 3) lessons learned from these early experiences; and 4) recommendations for future work and exploration in understanding the use of evidence-based planning and approaches in federal agencies and other organizations.