The Independent Evaluation of Comprehensive Primary Care Plus (CPC+): Third Annual Report to CMS covers the first three years of CPC+ for the 2,905 practices in regions that began CPC+ in 2017. The report examines (1) engagement in CPC+ by payer partners and health IT vendors and participation by practices; (2) the supports practices received; (3) how practices implemented CPC+ and changed the way they delivered health care; and (4) the impacts of CPC+ on cost, service use, limited claims-based quality-of-care outcomes, and patient experience for attributed Medicare fee-for-service beneficiaries three years into the five year model. An overview of findings from the Third Annual report is available in the two page Findings At a Glance.