Artificial intelligence in action

Mathematica applies responsible, human-in-the-lead AI to unlock insights, accelerate decision-making, and generate real-world impact across sectors.
From custom tools and automated document analysis to AI-enabled data platforms, our work streamlines complex workflows, reduces costs, and speeds agency operations while maintaining transparency, accuracy, and expert oversight. On this page, explore how our governed AI solutions deliver results with accountability and integrity at the forefront.
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How CMS used AI to cut hospital inquiry turnaround time by 35%

A custom AI tool created by Mathematica and its partner helped the Centers for Medicare & Medicaid Services (CMS) cut response times to certain hospital questions by 35 percent, delivering faster, clearer answers to providers. As agencies experiment with AI, CMS shows what governed AI can look like in practice, speeding operations without sacrificing accuracy, transparency, or expert oversight.

Could your agency benefit from governed AI?
Schedule a consultation with our healthcare AI team.
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Accelerating regulatory analysis with generative AI

A generative AI-powered chatbot developed by Mathematica helped CMS cut annual costs for an analysis of an agency rule by roughly 94 percent. The AI solution automated time-intensive document comparison, freeing experts to focus on higher-value policy analysis. The result was not just more efficient rulemaking but a scalable model for using AI to support smarter, more transparent decision making in health policy and beyond.

Reduce regulatory analysis costs without sacrificing oversight.
Speak with our AI policy experts.
Angled mockup of a Mathematica position paper titled ‘Framework for Evaluating LLMs on Complex Data Sets,’ showing the teal-and-navy cover with abstract network lines over hands on a laptop alongside open pages labeled ‘Executive Summary’ and ‘Problem Statement.’

Framework for evaluating LLMs’ handling of complex data sets

Most public evaluations of large language models (LLMs) rely on simplified or artificial data, making it hard to tell whether these tools can conduct the complex analyses used for real-world policymaking and research. To close that gap, Mathematica developed a prototype for a cloud-based LLM evaluation framework that tests how well different AI models analyze complex, survey-based data, helping organizations understand when and how AI can be used responsibly to support accurate, transparent decision making.

Evaluate AI before you deploy it.
Request a framework overview.

From our team

“In a recent project with the National Science Foundation, we demonstrated how generative AI can strengthen transparency and trust in federal statistics. We built a prototype platform that tracks how federal data assets are used across research, media, policy, and public reporting.

“By using AI as a classifier, quality-checker, chatbot, and coding assistant—while keeping humans in the lead—we improved data quality, reduced burden on government staff, and created a scalable model for turning complex information into accessible, trustworthy insights.”

Andrés Nigenda
Andrés Nigenda Zárate
Lead Data Scientist
 

Our principles

Mathematica applies AI responsibly, ethically, and with rigorous human‑in‑the‑lead oversight to safeguard privacy, security, and public trust.

Guided by our AI Principles & Position Statement, we use vetted enterprise‑grade tools, apply strict data‑protection and governance controls, and ensure that all AI‑supported work is reviewed by experts for accuracy, fairness, and alignment with client goals. Our comprehensive safeguards framework reflects our commitment to transparency, strong governance, and the responsible use of trusted data.

Clients interested in learning more about our organizational AI guardrails can contact us at info@mathematica-mpr.com for a detailed overview.

Meet some of our experts

Priya Narasimhan

Priya Narasimhan

Senior Director, Product Management

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Mark Flick

Mark Flick

Senior Director, Data Science and Analytics

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John Hotchkiss

John Hotchkiss

Lead Data Scientist

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Andrés Nigenda

Andrés Nigenda

Lead Data Scientist

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Loretta Cambron

Loretta Cambron

AI Transformation Director

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