In fall 2009, the U.S. Department of Health and Human Services (HHS) launched a systematic review of the research literature on programs to prevent teen pregnancy, sexually transmitted infections, and associated sexual risk behaviors. Findings have been used to inform two new federal policy initiatives aimed at supporting evidence-based approaches to teen pregnancy prevention. This research brief highlights six key lessons from the review, intended to help the growing number of organizations and federal agencies considering similar policy-driven reviews.