Agricultural and environmental outcomes are inextricably linked. Soil health, water availability, air quality, and climate change all influence crop productivity. Yet agriculture also drives deforestation, biodiversity loss, soil erosion, and soil and water pollution, and is responsible for over one-quarter of total greenhouse gas (GHG) emissions. Promising agricultural technologies that increase both productivity and positive environmental outcomes can greatly improve the sustainability of agriculture. Therefore, a fuller accounting of the benefits and costs of agricultural innovations can help optimize investments. Under the USAID-supported consortium led by Mathematica, Applied GeoSolutions, the Institut Sénégalais de Recherches Agricoles, and the Feed the Future Sustainable Intensification Innovation Lab, we are developing a sustainable agriculture decision support tool (DST) to fill this information gap and inform scale-up of innovative technologies that can help achieve “win–win” agricultural and environmental outcomes.